Modulation of antigen‐specific T‐cell activationin vitroby taurine chloramine

Taurine Chloramine Inhibits Inducible Nitric

Conversion of taurine into N-chlorotaurine (taurine chloramine) and sulphoacetaldehyde in response to oxidative stress.

N-Chlorotaurine (taurine chloramine), formed by treating taurine with hypochlorous acid, was shown to decompose to sulphoacetaldehyde with a first-order rate constant of 9.9+/-0.5 x 10(-4).h-1 at 37 degrees C in 0.1 M phosphate buffer, pH 7.4. Rat liver homogenates accelerated this decay in a process that was proportional to tissue-protein concentration and saturable, with maximum velocity (Vma...

Taurine and vascular tone modulation

Taurine, an ubiquitary amino acid in the organism, has important physiological functions like bile salt formation, neuronal excitability regulation, immunomodulation, electrolytes homeostasis preservation, osmoregulation, membrane stabilisation, apoptosis inhibition and cell protection. This review article is focusing on the complex vasoactive influence of the sulphur-amino acid and on the poss...

Taurine Modulation of Renal Excretory Function

Taurine is an important regulator of cellular ion transport and osmotic balance, aspects that are pivotal to renal function. The kidney not only regulates body taurine status, but emerging information also suggests that body taurine status is of consequence for renal function. While reduction in endogenous taurine stores can attenuate renal excretory function, exogenous taurine supplementation ...

Taurine chloramine protects RAW 264.7 macrophages against hydrogen peroxide-induced apoptosis by increasing antioxidants

Taurine chloramine is the major chloramine generated in activated neutrophils via the reaction between the overproduced hypochlorous acid and the stored taurine. Taurine chloramine has anti-inflammatory and cytoprotective effects in inflamed tissues by inhibiting the production of inflammatory mediators. Taurine chloramine increases heme oxygenase activity and also protects against hydrogen per...